Dr. Katou is an ambitious woman who seeks to revolutionize the corrupt and inefficient Japanese medical system from within by becoming a professor in a teaching hospital. She enlists a maverick surgeon, Dr. Asada Ryuutarou, to help her with research that would catapult her to a professorship should they succeed and publish. However, Asada's refusal to conform to the system soon threatens to destroy not only her plans but her entire career. Katou is prepared to do anything, including going along with the system, in order to achieve her end goal, but she begins to question whether she has gone too far as Asada's actions bring many of the system's shortcomings to light.

This manga received the 50th Shogakukan Manga Award for general manga in 2005.